Optic neuritis: Clinical, Immunological and experimental aspects.
Optic neuritis (ON) is an inflammatory demyelinating condition of the optic nerve that often occurs as the first clinical course of multiple sclerosis (MS) and neuromyelitis optica (NMO). Episodes of ON can cause considerable damage to the myelin sheath and nerve fibers resulting in impaired vision and blindness. ON patients who are seropositive for antibodies directed against the water channel aquaporin-4 (AQP4) are classified as suffering from NMO. Early distinction between MS and NMO is important due to differences in prognosis and treatment.
1. To investigate the disease course in patients with ON in order to provide earlier diagnosis of NMO ON.
2. To identify biomarkers in blood and CSF for the clinical development of ON.
3. To investigate optical coherence tomography (OCT) and magnetic resonance imaging (MRI) during the disease course in ON patients
4. To investigate pathogenic mechanisms in a mouse model of NMO ON
The study is translational as it combines clinical and immunological data from human and experimental studies.
1. september 2014 - 30. november 2017
Ph.d. er forsvaret
Torsdag den 25. januar 2018
Associate Professor, Consultant Nasrin Asgari, MD, PhD, Dept. of Neurology, Slagelse Hospital and Institute of Molecular Medicine, University of Southern Denmark.
Professor Jakob Grauslund, MD, PhD., DMSc, Dept. of Ophthalmology, OUH
Professor Trevor Owens, PhD, Institute of Molecular Medicine, University of Southern Denmark.
Publikationer og aktiviteter
Se link til Kerstin Soelberg's publikationer m.v. på SDU.dk - link